Percutaneous Collagen Induction Therapy

To make things easier a good starting point will be to clarify the words.


This ominously naughty sounding word is simply a medical term:


When using the word percutaneous, you will be applying a serum or active when you do the nanokiss skin needling. Let’s call it Wet skin needling. The active you apply whilst you nanokiss, can help speed up your skin renewal if the body has nutritional deficiencies. Our definition of it would be to apply a serum non-invasively on the dermis (living skin) with a microscopic needle without removing or damaging the epidermis (protective dead skin). Hint: An easy way to remember the word would be to think of a ‘coffee purculator’.


collagenTo date scientists have identified 28 different types of collagen. As a Nanokiss beautician you only need to know about Collagen type III and Collagen type I.Type III Collagen is a ‘temporary’ type collagen that forms in GRANULATION TISSUE after skin injury. Granulation tissue is new connective tissue and tiny blood vessels that form on the surfaces of a wound during the healing process. Granulation tissue typically grows from the base of a wound and is able to fill wounds of almost any size it heals. Type III Collagen is produced quickly by young fibroblasts before the tougher type I collagen is synthesized.

Over 90% of collagen in the human body is of type I. Depending on how the protein molecules are arranged the body creates bone, skin, cartilage etc. Along with soft keratin, it is responsible for skin strength and elasticity, and its degradation leads to wrinkles that accompany aging.Both ‘normal’ collagen and ‘scar’ collagen is of type I. Tough and protecting. The difference between ‘normal’ and scar collagen lies in the way the protein molecules was arranged during the repair cycle.Scar arranged collagen I molecules will only form if the skin wound is of a serious nature (e.g. after accident, disease, or surgery). Normal tissue has a random basket weave formation of the collagen fibers, in scar tissue the collagen cross-links and forms a pronounced alignment in a single direction. Minor lesions do not form scars and the tissue will grow back in the correct formation.


When you nanokiss you give the kiss that wakes up sleeping beauty. Your Nanokiss stimulates or induces younger skin behavior and growth.


Need we say more. Therapy is the act of caring for someone. As a Nanokiss beautician your cosmetic skin care results in fabulous younger looking skin.

A brief history of CIT

In reality CIT is as old as skin needling, which is as old as the first tattoo.

Tattooing has been a Eurasian practice at least since Neolithic times. Ötzi the Iceman, dating from the 5th to 4th millennium BC, was found in the Ötz valley in the Alps and had some 57 carbon tattoos consisting of simple dots and lines on his lower spine, behind his left knee, and on his right ankle. These tattoos were thought to be a form of healing because of their placement, which resembles acupuncture.Other mummies bearing tattoos and dating from the end of the 2nd millennium BC have been discovered, such as the Mummy of Amunet from ancient Egypt and the mummies at Pazyryk on the Ukok Plateau.

Even though CIT has indirectly nothing to do with tattooing, this ancient art of body adoring led to the discovery of amazing skin renewal, thousands of years later by accident, when a Canadian skin specialist observed that the injuries caused by the needle on the tattoo gun led to skin normalization in an area previously scarred.

In 1997,Dr Camirand a Canadian Skin Specialist, noticed to his amazement that the skin under a scar started returning to its healthy normal glow whilst he was doing cosmetic tattooing over the scar with the intention to hide it. Even the pigment he was using on the tattoo disappeared as normal skin tone returned. This baffled Dr Camirand and he decided to investigate further. He discovered that it was the injuries of the needling action of the tattoo needles itself that lead to the rebirth of younger skin. The tattoo gun created small injuries under the epidermis on the skin, as these wounds healed, something marvelous happened. Skin renewal and normalization as if though the person is younger.

Further pioneering work by skin specialists like Dr Des Fernadus, Matthias C. Aust, M.D., Perikles Kolokythas, M.D., Hilton M. Kaplan, M.D., Peter M. Vogt, M.D. and clinical trials done in Hannover, Germany; Cape Town, South Africa; Los Angeles, California, London UK and in Korea has proved Collagen Induction Therapy as a highly effective and safe cosmetic skin renewal procedure.

Since the introduction of percutaneous collagen induction therapy in 1997, it has evolved into a simple and fast method for safely treating wrinkles and scars and to produce smooth, even toned skin. As opposed to ablative laser treatments, or chemical skin peels, the epidermis remains intact and is not damaged. For this reason, the procedure can be repeated safely in 4 to 6 week intervals and is also suited to regions where laser treatments and deep peels cannot be performed.

In clinical trials done by the group of doctors mentioned above, 480 subjects (400 woman and 80 men) in different countries and age groups varying from 18 to 78. All of the subjects experienced improvement in the skin condition treated and after treatment, none of the patients experienced any photo sensitivity or developed any post inflammatory hyper pigmentation or hypo pigmentation.

CIT is now the fastest growing beauty treatment on the planet and hundreds of thousands of treatments has been done since the early pioneering days of Dr Camirand. The modern invention of the nanokiss and disposable nano and micro needle cartridges makes CIT an affordable, safe skin renewable treatment for anyone with skin marring problems and for those who want to look younger again.

The process explained step by step.

Collagen induced by the Nanokiss device.

Let’s follow the effect of a single needle punched by the nanokiss cartridge and discover the amazing miracle of natural skin regeneration lying dormant in your body. When the tiny micro or nano needle punches a precise hole through the dead skin into the upper regions of the living skin tissue (dermis) it causes a fractionally small wound in the dermis. And when I say small, I mean really, really small. So small you can only see it with a microscope. If you do a wet (percutaneous) nanokiss some of the active will be delivered in the dermis, to aid and speed up skin regeneration.

Every single living cell in your body is connected to your blood stream. so when an injury extends through the epidermis into the dermis, bleeding occurs. Healing starts immediately with a process called Hemostasis. The sentence above is deliberately highlighted and bold to emphasize the fact that bleeding occurs when the dermis has been penetrated regardless of the size of the wound, as a beautician you do not have to visibly see blood flowing to induce collagen.

On a microscopic injury scale, bleeding will occur and will almost instantly be stopped. The body’s prime protective motive is to stop bleeding and close the injury to prevent hostile matter to enter the body no matter how small the wound. The smaller the wound, the smaller the bleeding, the faster the healing. A matrix of small wounds created in any damaged area of the skin, regenerates skin perfectly in the matrix area.

Hemostasis, nature starts skin renewal.

· Platelets quickly cover the area to seal the wound in seconds. The entire micro channel will be closed within 15 minutes (Coagulation) · A type of immune cell, called the neutrophil, arrives and sterilizes the damaged area. · Another type of immune cell called a macrophage arrives after the neutrophils have sterilized the tissue. The macrophage begins to ingest the skin debris produced by the damage and also secrete about 20 different growth factors needed for proper skin repair. These have names such as epidermal growth factor, fibroblast growth factor, platelet-derived growth factor among others. (Natures Peptides) · The released growth factors increases the production of collagen III and elastin. (The new skin cells will be plumper because of the additional collagen and elastin)

Within days a process is initiated in which collagen type III is converted into collagen type I, the temporary scar tissue is removed and replaced with normal skin tissue. · New skin growth can continue for up to a year. The ability of the skin to heal perfectly after minor damage is due to the presence of stem cells in the dermis and cells in the stratum basale of the epidermis, all of which can generate new tissue when stimulated. With the Nanokiss a fine matrix of precise depth controlled channels are created instantly over the area of the skin being treated resulting in even natural skin renewal.

When treating skin areas previously scarred or pigment damaged by the sun, the process of nanokissing also transfers stem cells on the tiny needles from healthy areas to areas lacking in stem cells, thus regenerating normal skin, not naturally possible before the nanokiss. What we mean by this is that when an area is scarred or pigmented it will remain to look like a scar even when natural skin shedding and replacement occurs. A nanokiss assists nature to regenerate skin like it did when you were younger.

The epidermis is a complex, highly specialized protective layer, even though it is only approximately 0.2 mm thick. We should never destroy the epidermis for aesthetic reasons. Skin renewal under the epidermis is safer and longer lasting than ANY method used when the epidermis is removed.

A time line of skin renewal. (Healing)







(Image courtesy of Wikipedia Commons)